The latest study done by the scientists at the Texas Tech University Health Science Centre has clarified that the changing genes can be a reason for long-term symptoms caused by the Covid-19. Notably, this research was done on the people who have experienced the Coronavirus infection and have recovered. The virus that causes the Covid-19 named the SARS-CoV-2, is said to be covered in spike proteins. Notably, this binds with the receptors on cells in the body during infection. Further, this initiated a process that allows the virus to release its genetic material into the healthy cell.
Nicholas Evans, a masters student at the Texas Tech University Health Sciences Center, in a press release said, “we found that exposure to the SARS-CoV-2 spike protein alone was enough to change baseline gene expression in airway cells.” Furthermore, he added, “This suggests that symptoms seen in patients may initially result from the spike protein interacting with the cells directly.” Notably, the researchers have discovered that the cultured human airway cells expose to both low and high concentrations of the spike protein. Thus, they showed differences in gene expression that remained even after the cells recovered. This includes the genes related to hypoxia, cell death, inflammatory response, and DNA damage, etc.
This is to say, the researchers found the findings may indicate that even those with asymptomatic COVID infections could still have long-lasting changes in genetic expression. The researchers made a new approach to enlighten the airway cells to more closely simulate the physiological conditions in the lung airway. This entire process involved exposing the cells to air and giving them time to mature into airway cells. This is to say, the researchers plan to utilize the latest approach to study how long the genetic changes last and the potential long-term consequences of the changes.